Structural Biology and Genome Informatics
Bhupesh Taneja
Scientist-G |
Decision Unit 6: Infectious Disease Biology
Professor |
Academy of Scientific and Innovative Research
Bhupesh Taneja's lab investigates host-pathogen interactions at a molecular level using protein crystallography and genome informatics of key cellular pathways. Antimicrobial resistance in bacteria (including mycobacteria) as well as in dermatophytic fungi (that cause skin infections) is one of the key areas of their current research focus.
Specific Interests
- Structural insights into nucleotide modifying and regulatory proteins of M. tuberculosis
- Understanding the molecular basis of fungal skin infections by dermatophytes
Selected Publications
All Citations →- Three-dimensional structure of a mycobacterial oligoribonuclease reveals a unique C-terminal tail that stabilizes the homodimer. Badhwar P, Khan SH, Taneja B. J Biol Chem. 2022 Dec;298(12):102595.
- Structural investigation and gene deletion studies of mycobacterial oligoribonuclease reveal modulation of c-di-GMP-mediated phenotypes. Badhwar P, Ahmad I, Sharma R, Taneja B. Int J Biol Macromol. 2022 Dec 31;223(Pt A):161–172.
- A Dual-Plasmid-Based CRISPR/Cas9-Mediated Strategy Enables Targeted Editing of pH Regulatory Gene pacC in a Clinical Isolate of Trichophyton rubrum. Dey S, Ramalingam S, Taneja B. J Fungi (Basel). 2022 Nov 24;8(12):1241.
- Biophysical characterization of the C-terminal tail of T. rubrum pacC reveals an inherent intrinsically disordered structure with pH-induced structural plasticity. Dey S, Chakraborty R, Taneja B. ACS Omega. 2022 Dec 19;8(1):357–364.
- Whole genome sequences of two Trichophyton indotineae clinical isolates from India emerging as threats during therapeutic treatment of dermatophytosis. Kumar P, Das S, Tigga R, Pandey R, Bhattacharya SN, Taneja B. 3 Biotech. 2021 Sep;11(9):402.