Krishnendu Chakraborty
Scientist-E |
Decision Unit 6: Infectious Disease Biology
Professor |
Academy of Scientific and Innovative Research
Inflammation is a double-edged sword—while essential for clearing pathogens, uncontrolled inflammation can cause severe tissue damage. Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are critical conditions associated with high mortality due to dysregulated inflammatory responses.
These diseases often begin with a hyper-inflammatory phase followed by immunosuppression, increasing susceptibility to secondary infections. Mitochondrial DAMPs such as cardiolipin (CL) play a crucial role by interfering with inflammation resolution mechanisms like IL-10 production.
Krishnendu Chakraborty's research focuses on understanding how mitochondrial DAMPs influence ALI severity, studying both early and late disease phases. His work integrates basic biology, animal models, and patient samples to develop therapeutic strategies.
Specific Interests
- Mechanisms regulating IL-10 suppression during early ALI
- Impact of cardiolipin on immune cell metabolism and macrophage polarization
- Immune evasion by multidrug-resistant Klebsiella pneumoniae
Selected Publications
All Citations →- Immunomodulatory role of mitochondrial DAMPs: a missing link in pathology? Garg M, Johri S, Chakraborty K. The FEBS Journal. 2022.
- Cardiolipin-mediated PPARγ S112 phosphorylation impairs IL-10 production and inflammation resolution during bacterial pneumonia. Garg M, Johri S, Sagar S, Mundhada A, Agrawal A, Ray P & Chakraborty K. Cell Rep. 2021;34(6):108736.
- The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia. Chakraborty K, Raundhal M, Chen BB, Morse C, Tyurina YY, Khare A, Oriss TB, Huff R, Lee JS, St Croix CM, Watkins S, Mallampalli RK, Kagan VE, Ray A, Ray P. Nat Commun. 2017;8:13944.
- Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias. Gauthier M, Chakraborty K, Oriss TB, Raundhal M, Das S, Chen J, Huff R, Sinha A, Fajt M, Ray P, Wenzel SE, Ray A. JCI Insight. 2017;2(13).
- Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-kB Activation to Prevent Unwarranted Immune Activation. Khare A, Raundhal M, Chakraborty K, Das S, Corey C, Kamga CK, Quesnelle K, St Croix C, Watkins SC, Morse C, Oriss TB, Huff R, Hannum R, Ray P, Shiva S, Ray A. Cell Rep. 2016;15(8):1700–14.