Munia Ganguli
Scientist-G |
Decision Unit 3: Chemical Biology
Professor |
Academy of Scientific and Innovative Research
Munia Ganguli works on designing nanoparticles for efficient and safe therapeutic cargo delivery. The primary focus is localized and systemic delivery of nucleic acids in vivo to organs like skin, muscle, and brain using designed peptides and polymers. The lab also develops functionalized nanoparticles for applications ranging from UV protection to cancer drug delivery.
Specific Interests
- Peptide & polymer-based nanocomplexes for gene delivery
- Safe delivery of therapeutic nucleic acids to skin and muscle
- Functionalized nanoparticles for biomedical applications
The group has developed peptide-based nanocomplexes for gene delivery and polymer systems capable of crossing the blood-brain barrier. Current work includes mRNA delivery and CRISPR-Cas9 based gene editing. They have also developed UV protectants and cold-protection systems for skin applications.
Selected Publications
All Citations →- A combination of systemic mannitol and mannitol modified polyester nanoparticles for caveolae-mediated gene delivery to the brain. Gilbert BR, Miglani C, Karmakar A, Pal M, Chandran VC, Gupta S, Pal A, Ganguli M. Mol Ther Nucleic Acids. 2025 Feb 6;36(1):102480.
- Sugar alcohol-modified polyester nanoparticles for gene delivery via selective caveolae-mediated endocytosis. Reshma G B, Miglani C, Pal A, Ganguli M. Nanoscale. 2024 Feb 22;16(8):4114-4124.
- Albumin Nanoparticles Surface Decorated with a Tumor-Homing Peptide Help in Selective Killing of Triple-Negative Breast Cancer Cells. Pal S, G BR, Mohny FP, Choudhury SG, Karmakar A, Gupta S, Ganguli M. ACS Appl Mater Interfaces. 2023 Oct 11;15(40):46721-46737.
- Surface-Engineered Mucus Penetrating Nucleic Acid Delivery Systems with Cell Penetrating Peptides for the Lungs. Kumari A, Pal S, G BR, Mohny FP, Gupta N, Miglani C, Pattnaik B, Pal A, Ganguli M. Mol Pharm. 2022 May 2;19(5):1309-1324.
- A Combination of Synthetic Molecules Acts as Antifreeze for the Protection of Skin against Cold-Induced Injuries. Gupta A, Reshma G B, Singh P, Kohli E, Sengupta S, Ganguli M. ACS Appl Bio Mater. 2022 Jan 17;5(1):252-264.