Rajesh Pandey
Scientist-F |
Decision Unit 6: Infectious Diseases Biology
Professor |
Academy of Scientific and Innovative Research
Rajesh Pandey's lab harnesses the power of genomics to understand genome regulatory features influencing disease severity and clinical outcomes in host-pathogen interactions. The work explores dynamic interactomes involving pathogens, host responses (coding and noncoding), transcriptionally active microbes (TAMs), alternate transcript isoforms, antimicrobial resistance (AMR), and phages.
The lab utilizes advanced tools including whole genome sequencing (WGS), bulk and single-cell RNA sequencing, and Ab-seq to decode molecular mechanisms underlying infectious diseases.
Specific Interests
- Transcriptionally Active Microbes (TAMs) in disease severity
- Role of AMR and phages in disease pathogenesis
- Alternate transcript isoforms as indicators of disease states
His lab has leveraged WGS-based pathogen genomics from clinical datasets to improve public health management, including insights into drug efficacy such as Remdesivir for COVID-19.
Integrative genomics approaches combining bulk and single-cell RNA-seq have revealed immune dynamics driven by coding and non-coding RNAs, contributing to immuno-genomics and global research advancements.
Selected Publications
All Citations →- Metatranscriptomic insights into the dengue patient blood microbiome: Enhanced microbial diversity and metabolic activity in severe patients. Yadav A, Devi P, Kumari P, Shamim U, Tarai B, Budhiraja S, Pandey R*. PLOS Neglected Tropical Diseases, 2024.
- TCR repertoire dynamics and their responses underscore dengue severity. Khare K*, Yadav S, Tarai B, Budhiraja S, Pandey R*. iScience, 2024.
- Reduced protein-coding transcript diversity in severe dengue emphasizes the role of alternative splicing. Mehta P, Liu CSC, Sinha S, Mohite R, Arora S, Chattopadhyay P, Budhiraja S, Tarai B, Pandey R*. Life Science Alliance, 2024.
- Cell-specific housekeeping role of lncRNAs in COVID-19-infected and recovered patients. Chattopadhyay P, Mehta P, Soni J, Tardalkar K, Joshi M, Pandey R*. NAR Genomics and Bioinformatics, 2024.
- Functional metagenomics highlights varied infection states with dynamics of pathogens and antibiotic resistance in lower respiratory tract infections. Shamim U, Yadav A, Maurya R, Devi P, Kumari P, Kanika, Khare K, Tarai B, Pandey R*. Heliyon, 2024.