Sheetal Gandotra
Scientist-F |
Decision Unit 6: Infectious Diseases Biology
Professor |
Academy of Scientific and Innovative Research
Sheetal Gandotra's lab studies host–pathogen interactions in tuberculosis with a focus on lipid metabolism. The research explores how lipid droplets—key storage organelles in immune cells—modulate innate immune responses to intracellular pathogens.
Specific Research Interests
- Lipid droplet proteins in innate immune defense
- Mycobacterial lipid metabolism
Her group discovered that triglyceride synthesis in human macrophages influences the inflammatory response to infection. These triglycerides are stored in lipid droplets, whose protein composition is actively altered by Mycobacterium tuberculosis. Current research focuses on how these proteins regulate lipid mobilization and immune responses, contributing to host-directed therapies for tuberculosis.
Selected Publications
All Citations →- Inhibition of Granuloma Triglyceride Synthesis Imparts Control of Mycobacterium tuberculosis Through Curtailed Inflammatory Responses. Dawa S, Menon D, Arumugam P, Bhaskar AK, Mondal M, Rao V, Gandotra S. Front Immunol. 2021 Sep 15;12:722735.
- Quantitative Lipid Droplet Proteomics Reveals Mycobacterium tuberculosis Induced Alterations in Macrophage Response to Infection. Menon D, Singh K, Pinto SM, Nandy A, Jaisinghani N, Kutum R, Dash D, Prasad TSK, Gandotra S. ACS Infect Dis. 2019 Apr 12;5(4):559-569.
- Necrosis Driven Triglyceride Synthesis Primes Macrophages for Inflammation During Mycobacterium tuberculosis Infection. Jaisinghani N, Dawa S, Singh K, Nandy A, Menon D, Bhandari PD, Khare G, Tyagi A, Gandotra S. Front Immunol. 2018 Jul 3;9:1490.
- Adipocyte Model of Mycobacterium tuberculosis Infection Reveals Differential Availability of Iron to Bacilli in the Lipid-Rich Caseous Environment. Nandy A, Mondal AK, Pandey R, Arumugam P, Dawa S, Jaisinghani N, Rao V, Dash D, Gandotra S. Infect Immun. 2018 May 22;86(6).
- Tuning the Mycobacterium tuberculosis Alternative Sigma Factor SigF through the Multidomain Regulator Rv1364c and Osmosensory Kinase Protein Kinase D. Misra R, Menon D, Arora G, Virmani R, Gaur M, Naz S, Jaisinghani N, Bhaduri A, Bothra A, Maji A, Singhal A, Karwal P, Hentschker C, Becher D, Rao V, Nandicoori VK, Gandotra S, Singh Y. J Bacteriol. 2019 Mar 13;201(7):e00725-18.