Nucleic Acid Biophysics
Professor | Academy of Scientific and Innovative Research
Souvik Maiti
Director
Scientist-G | Decision Unit 3: Chemical BiologyProfessor | Academy of Scientific and Innovative Research
Souvik Maiti studies unusual nucleic acid structures and their biological roles, particularly in non-coding RNA. His research focuses on targeting these structures using chemically engineered oligonucleotides and small molecules.
Specific Interests
- RNA G-quadruplexes and their role in gene expression regulation
- Small molecule modulators of miRNA function as therapeutic leads
His research has shown that RNA G-quadruplex motifs can enhance translation, such as in the 5' UTR of TGFB2. Additionally, his lab demonstrated the repurposing of streptomycin to suppress oncogenic miRNA (miR-21), highlighting new therapeutic possibilities.
Selected Publications
All Citations →- Small molecule quercetin binds MALAT1 triplex and modulates its cellular function. Rakheja I, Ansari AH, Ray A, Joshi DC, Maiti S. Mol Ther Nucleic Acids. 2022 Sep 23;30:241–256.
- Alternative splicing modulation mediated by G-quadruplex structures in MALAT1 lncRNA. Ghosh A, Pandey SP, Ansari AH, Sundar JS, Singh P, Khan Y, … Maiti S. Nucleic Acids Res. 2022 Jan 11;50(1):378–396.
- Rapid identification and tracking of SARS-CoV-2 variants of concern. Chakraborty D, Agrawal A, Maiti S. Lancet. 2021 Mar 22:S0140-6736(21)00470-0.
- Rapid and accurate nucleobase detection using FnCas9 and its application in COVID-19 diagnosis. Azhar M, Phutela R, Kumar M, Ansari AH, Rauthan R, Gulati S, … Maiti S. Biosens Bioelectron. 2021 Jul 1;183:113207.
- Fine-tuning miR-21 expression and inhibition of EMT in breast cancer cells using aromatic-neomycin derivatives. Ghosh A, Ranjan N, Jiang L, Ansari AH, Degyatoreva N, Ahluwalia S, … Maiti S. Mol Ther Nucleic Acids. 2021 Dec 21;27:685–698.