Aastha Mishra
Scientist-E |
Decision Unit 1: Genomics and Genome Biology
Professor |
Academy of Scientific and Innovative Research
Aastha Mishra studies the effect of harsh environmental factors on disease risk and health outcomes through modified epigenetics phenomena and differential genetic variants. Her laboratory utilizes multimodal translational and functional aspects of genome sequencing to understand hypoxic-driven molecular insights. Additionally, her group identifies the causative pathogenic variations related to cardiovascular disorders, enabling genotype-phenotype guided disease management strategy.
Specific Interests
- Circulating nucleic acids in disease pathogenesis in humans under extreme environments
- Effect of Remote Ischemic Conditioning in pulmonary fibrosis-induced in vivo model
- Identification of pathogenic variations related to cardiovascular disorders in Indian population
Her group has identified the causal inferences to genomics and epigenomics analysis in pulmonary vascular disorders. Her studies have established crucial genetics and epigenetic role of oxygen sensing pathways in adaptive and non-adaptive physiological responses at high-altitude.
Additionally, her lab observed altered cell-free DNA fragment patterns in high-altitude pulmonary edema patients correlating with peripheral oxygen saturation levels. These patterns are deep-sequenced to identify cell-free gene-regulatory networks associated with hypoxia response.
Selected Publications
All Citations →- Hypobaric hypoxia modulated structural characteristics of circulating cell free DNA in high altitude pulmonary edema. Ali M, Choudhary R, Singh K, Kumari S, Kumar R, Graham BB, Pasha MAQ, Rabyang S, Thinlas T, Mishra A. Am J Physiol Lung Cell Mol Physiol. 2024;326(4):L496–L507.
- Association of transient mitochondrial functional impairment with acute heat exposure in children from Muzaffarpur region of Bihar, India. Singh K, Kumari S, Ali M, Das MK, Mishra A, Singh AK. Int J Biometeorol. 2023;67(12):1975–1989.
- Respiratory tract infection: An unfamiliar risk factor in high-altitude pulmonary edema. Raushni Choudhary, Swati Kumari, Manzoor Ali, Tashi Thinlas, Stanzen Rabyang, Aastha Mishra. Brief Funct Genomics. 2024;23(1):38–45.
- Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high altitude pulmonary edema. Sharma K, Mishra A, Singh H, Thinlas T, Pasha MAQ. Clin Epigenetics. 2022;14(1):123.
- High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases. Sharma K, Mishra A, Singh HN, Parashar D, Alam P, Thinlas T, Mohammad G, Kukreti R, Syed MA, Pasha MAQ. Hum Mol Genet. 2021;30(18):1734–1749.