Aastha Mishra
Scientist-E |
Decision Unit 1: Genomics and Genome Biology
Professor |
Academy of Scientific and Innovative Research
Aastha Mishra studies the effect of harsh environmental factors on disease risk and health outcomes through modified epigenetics phenomena and differential genetic variants. Her laboratory utilizes multimodal translational and functional aspects of genome sequencing to understand hypoxic-driven molecular insights. Additionally, her group identifies the causative pathogenic variations related to cardiovascular disorders, enabling genotype-phenotype guided disease management strategy.
Specific Interests
- Circulating nucleic acids in disease pathogenesis in humans under extreme environments
- Effect of Remote Ischemic Conditioning in pulmonary fibrosis-induced in vivo model
- Identification of pathogenic variations related to cardiovascular disorders in Indian population
Her group has identified the causal inferences to genomics and epigenomics analysis in pulmonary vascular disorders. Her studies have established crucial genetics and epigenetic role of oxygen sensing pathways in adaptive and non-adaptive physiological responses at high-altitude.
Additionally, her lab observed altered cell-free DNA fragment patterns in high-altitude pulmonary edema patients correlating with peripheral oxygen saturation levels. These patterns are deep-sequenced to identify cell-free gene-regulatory networks associated with hypoxia response.
Selected Publications
All Citations →- Cell-free genome analysis reveals pathophysiological response to hypoxia at high altitude. Raushni Choudhary, Manzoor Ali, Krishna Kumar G, Kanika Singh, Stanzen Rabyang, Tashi Thinlas, Rahul Kumar, Brian B. Graham, Kumardeep Chaudhary, Aastha Mishra. Physiol Genomics. (Articles in Press).
- Remote ischemic conditioning mitigates diesel exhaust-induced pulmonary fibrosis by alleviating pulmonary inflammation and fibrogenesis. Swati Kumari, Kaushlendra Mishra, Kanika Singh, Krishna Kumar G, Rohit Kumar, Abhishek Parihar, Rani Kumari, Ekta Nagar, Naveen Arora, Vishal Bansal, Aastha Mishra. Sci Rep. 2026.
- To Descend or Not: Is Sea Level Relocation Essential for PAH Patients at High Altitude? Aastha Mishra. CHEST. 2026 Aug;170(2):301–302.
- Integrated cytokine and immune cell profiling reveals a distinct immune signature associated with high-altitude pulmonary edema. Kanika Singh, Manzoor Ali, Krishna Kumar G., Tsering Palmo, Swati Kumari, Tashi Thinlas, Qadar Pasha, Brian B. Graham, Aastha Mishra*, Rahul Kumar*. Int J Mol Sci. 2026;27(17):7787.
- Integrative blood profiling uncovers inflammatory network signatures in high altitude pulmonary edema. Kanika Singh, Krishna Kumar, Manzoor Ali, Raushni Choudhary, Mohit Khadia, Stanzen Rabyang, Tashi Thinlas, Rahul Kumar, Aastha Mishra. Biosci Rep. 2025;45:1–20.