Neeru Saini
Scientist-G |
Decision Unit 2: Disease Biology and Therapeutics
Professor |
Academy of Scientific and Innovative Research
Dr. Saini's research focuses on miRNA-mediated regulation of apoptosis and its therapeutic potential. Her lab has identified multiple miRNAs with clinical relevance and is exploring cholesterol metabolism regulation through microRNAs.
Key Research Interests
- Role of microRNAs in mitochondrial function and regulation
- microRNA-based therapeutics and diagnostics for cancer and psoriasis
- Use of Adipose Derived Stem Cells (ADSC) for drug discovery
De novo lipogenesis plays a critical role in cancer progression. Her lab identified ACACA, FASN, HMGCR, and CYP27B1 as targets of hsa-miR-195. Its expression reduces proliferation, invasion, and migration in cancer cells while improving epithelial traits, opening new therapeutic pathways in breast cancer.
Selected Publications
All Citations →- MicroRNA-128 inhibits mitochondrial biogenesis and function via targeting PGC1α and NDUFS4. Sharma K, Chandra A, Hasija Y, Saini N. Mitochondrion. 2021 Sep;60:160-169.
- Inhibition of microRNA-128-3p attenuates hypercholesterolemia in mouse model. Chandra A, Sharma K, Pratap K, Singh V, Saini N. Life Sci. 2021 Jan 1;264:118633.
- Mitochondrial microRNA (MitomiRs) in cancer and complex mitochondrial diseases: current status and future perspectives. Purohit PK, Saini N. Cell Mol Life Sci. 2021 Feb;78(4):1405-1421.
- PI3K/AKT/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis. Varshney P, Saini N. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1795-1803.
- miR-4516, a microRNA downregulated in psoriasis inhibits keratinocyte motility by targeting fibronectin/integrin α9 signaling. Chowdhari S, Sardana K, Saini N. Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3142-3152.