Rakesh Sharma
Scientist-G |
Decision Unit 1: Genomics and Genome Biology
Professor |
Academy of Scientific and Innovative Research
Rakesh Sharma is interested in understanding microbial diversity and functions in environment and host using metagenomics and molecular genetics.
Specific Interests
- Microbiome as a source of novel bioactive molecules and peptides
- Stress tolerance and arsenic detoxification mechanisms from microbial communities
- Metal ion homeostasis and membrane transporters in Mycobacteria
His group has identified a novel calcium uptake transporter of the P-type ATPase superfamily and demonstrated its importance for cell wall integrity in Mycobacterium smegmatis. The group is also working on exploiting the human microbiome for novel antimicrobials. Several microbial isolates from human skin, including a new genus (Auricoccus indicus), have been identified, many producing antimicrobial compounds and peptides.
Selected Publications
All Citations →- Structural investigation and gene deletion studies of mycobacterial oligoribonuclease reveal modulation of c-di-GMP-mediated phenotypes. Badhwar P, Ahmad I, Sharma R, Taneja B. Int J Biol Macromol. 2022 Dec 31;223(Pt A):161-172.
- Loss of U1498 methylation in 16S rRNA by RsmE methyltransferase associates its role with aminoglycoside resistance in mycobacteria. Bijpuria S, Sharma R, Taneja B. J Glob Antimicrob Resist. 2020 Dec;23:359-369.
- Discovery of a diverse set of esterases from hot spring microbial mat and sea sediment metagenomes. Ranjan R, Yadav MK, Suneja G, Sharma R. Int J Biol Macromol. 2018 Nov;119:572-581.
- Bio-hydrogen production by co-digestion of domestic wastewater and biodiesel industry effluent. Prakash J, Sharma R, Patel SKS, Kim IW, Kalia VC. PLoS One. 2018 Jul 11;13(7):e0199059.
- A Novel Calcium Uptake Transporter of Uncharacterized P-Type ATPase Family Supplies Calcium for Cell Surface Integrity in Mycobacterium smegmatis. Gupta HK, Shrivastava S, Sharma R. mBio. 2017 Sep 26;8(5):e01388-17.